Human BCR_ABL (P465S) BAF3 Cell Line

Description

Human BCR_ABL (P465S) BAF3 Overexpression Cell Line is generated by introducing the human BCR-ABL fusion gene with a P465S point mutation into Ba/F3 cells via lentiviral transduction. The cells are kept under low passage (<P20) and validated by qRT-PCR. Target The BCR-ABL fusion is a constitutively active tyrosine kinase that drives chronic myeloid leukemia (CML). The P465S mutation is associated with altered kinase conformation and resistance to tyrosine kinase inhibitors (TKIs). AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Application

• For research use only
  

• This cell line is used to study TKI resistance mechanisms and to evaluate next-generation inhibitors targeting mutant forms of BCR-ABL in CML therapy.