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Transfected Stable Cell Lines

Human BRAF (K601N) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0035C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The BRAF (K601N) BAF3 cell line is an important tool for studying BRAF-driven tumors, supporting in-depth exploration of drug resistance mechanisms.

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  • Human BRAF (K601N) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (K601N) BAF3 Cell Line

Description

Human BRAF (K601N) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. BRAF (K601N) BAF3 mutant cell line is generated by stable integration of exogenous human BRAF gene harboring the K601N mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
BRAF is a serine/threonine-protein kinase that functions in the RAS/RAF/MEK/ERK signaling cascade, controlling cell growth and survival. The K601N mutation is a class II BRAF mutation that promotes constitutive dimerization and activation independent of upstream RAS input. This variant is frequently detected in non-V600E cancers and contributes to therapy resistance in BRAF-targeted treatments. AcceGen offers custom-engineered stable overexpression models for a variety of oncogenic mutations. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0035C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The BRAF (K601N) BAF3 Cell Line is a valuable tool for elucidating non-V600E BRAF signaling and testing MEK/ERK pathway inhibitors. It supports drug discovery efforts, mechanism-of-action studies, and the exploration of resistance pathways in BRAF-driven malignancies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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