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Human BRAF (L597Q) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (L597Q) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0047C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human BRAF (L597Q) NIH/3T3 Cell Line is a genetically engineered model derived from murine NIH/3T3 fibroblast cells based on customers’ requirement. BRAF (L597Q) NIH/3T3 mutant cell line is developed through stable lentiviral-mediated integration of the human BRAF gene containing the L597Q mutation.
Target
The L597Q mutation in BRAF lies adjacent to the activation segment of the kinase domain and leads to enhanced dimerization and increased downstream MEK/ERK pathway activation. It is recurrently observed in melanoma and other solid tumors, particularly in non-V600E mutant contexts. AcceGen specializes in generation of BRAF-mutant cell lines for oncogenic mechanism studies. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The BRAF (L597Q) NIH/3T3 Cell Line provides a potent tool to explore BRAF dimerization, mutation-specific signaling, and therapeutic vulnerabilities. It supports targeted drug screening, resistance analysis, and functional cancer genomics.

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