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Transfected Stable Cell Lines

Human BRAF (L597R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0279C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human BRAF (L597R) BAF3 Cell Line supports detailed investigation of BRAF mutation-driven oncogenic signaling and drug response in cancer models.

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  • Human BRAF (L597R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (L597R) BAF3 Cell Line

Description

Human BRAF (L597R) BAF3 Cell Line is a genetically engineered model derived from murine pro-B Ba/F3 parental cells based on customers’ requirement. BRAF (L597R) BAF3 overexpression cell line is generated by stable lentiviral transduction of human BRAF with the L597R mutation. Overexpression clone is validated by qRT-PCR.
Target
BRAF L597R is a less common activating mutation located in the kinase domain. It promotes dimerization-independent MEK activation and is implicated in a subset of melanomas and gliomas. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0279C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line is suitable for understanding the unique biology of non-V600 BRAF mutations, functional assays, and testing RAF/MEK pathway inhibitors targeting this class of alterations.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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