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Primary Cells

Human Brain Microvascular Endothelial Cells

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Human Brain Microvascular Endothelial Cells were initiated by elutriation of dispase dissociated normal human brain cortex tissue. These cells were originated using Complete Serum-Free Medium Kit, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells.
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Brain Microvascular Endothelial Cells
Species

Human
Cat.No

ABC-TC3524
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Ship cryopreserved cells in dry ice
-Quality-tested for accurate results

Description

Human Brain Microvascular Endothelial Cells (HBMECs) are isolated from the human brain tissues. Brain Microvascular Endothelial Cells (BMECs) form the interface between circulating blood and neural tissue, maintaining the blood-brain barrier (BBB) and regulating the CNS (central nervous system) homeostasis. Endothelial cells (ECs) are flat with a central, elongated nucleus at the microscopic level. Studies have found that compounds such as glucose, amino acids and exogenous drugs can enter brain tissue through special transport proteins expressed in BMECs, including transferrin receptor, insulin-like growth factor receptor, and angiotensin receptor . These cells also express tight junction proteins like claudin-5, occludin, and ZO-1 that form the structural basis of the BBB’s selective permeability.

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Citation

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Application

  • Human Brain Microvascular Endothelial Cells (HBMECs) can be used to study the mechanism of pathogens (such as bacteria and viruses) penetrating the BBB and to evaluate the delivery efficiency of drugs to the central nervous system. In the study of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, HBMECs are used to analyze the association between vascular dysfunction and pathological development.

Frequently Asked Questions

  • What are the primary research applications of Human Brain Microvascular Endothelial Cells?

    These cells are commonly used in studies of the blood-brain barrier, neuroinflammation, and drug transport across the brain endothelium.

  • What are the recommended culture conditions for Human Brain Microvascular Endothelial Cells?

    These cells should be cultured in a specialized endothelial growth medium, under standard cell culture conditions (37°C, 5% CO2).

  • What functional assays can be used with Human Brain Microvascular Endothelial Cells?

    Functional assays for Human Brain Microvascular Endothelial Cells include permeability assays, transendothelial electrical resistance (TEER) measurements, and migration assays. These assays are used to study the barrier properties and dynamics of these cells.

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