Human Brain Vascular Adventitial Fibroblasts

Description

Human Brain Vascular Adventitial Fibroblasts are primary cells isolated from human brain cerebral vascular tissue. Isolated from both healthy and diseased brains, they are preferably obtained and cryopreserved at early passage to maintain native characteristics. They typically exhibit spindle-shaped morphology and adherent growth in a monolayer. Functionally, they are essential for cerebrovascular homeostasis, synthesizing and maintaining the extracellular matrix in the brain’s vascular adventitia, supporting vascular tone, and mediating fibroblast responses to injury. Abnormalities in these cells are associated with cerebrovascular diseases such as cerebral arteriosclerosis. These human cells express vimentin. While demonstrating reasonable expansion capacity under optimized culture conditions, these primary cells should not undergo repeated freeze-thaw cycles to maintain optimal performance in cerebrovascular research applications. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.