Human Breast Cancer Peripheral Blood Mononuclear Cells

Description

Human Breast Cancer Peripheral Blood Mononuclear Cells (PBMCs) are isolated from peripheral blood of patients with histologically confirmed breast carcinoma, encompassing major subtypes including hormone receptor-positive (ER/PR⁺), HER2⁺, and triple-negative breast cancer (TNBC). These human-derived PBMCs contain lymphocytes (T cells, B cells, NK cells) and monocytes that exhibit breast cancer-specific immune alterations, including increased exhausted PD-1⁺CD8⁺ T cells, elevated Treg population (CD4⁺CD25⁺FoxP3⁺), and tumor-educated monocytes. The cells display typical mononuclear morphology with intact surface markers and maintain functional cytokine production (IFN-γ, IL-10, TGF-β) in response to tumor antigens. They are particularly valuable for studying the distinct immunobiology of different breast cancer subtypes, which vary significantly in tumor mutational burden and immune infiltration. Additionally, these PBMCs serve as a robust immune research tool under tc4350 for exploring systemic anti-tumor immune regulation and evaluating immunotherapeutic responses across breast cancer subtypes.