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Human C. Difficile Peripheral Blood Mononuclear Cells

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Clostridioides difficile (also known as C. diff) is a bacterium that causes diarrhea and colitis (an inflammation of the colon).
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Home | Primary Cells | Human Primary Cells | PBMCs | Human C. Difficile Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4361
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Clostridioides difficile
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Clostridioides Difficile Peripheral Blood Mononuclear Cells are derived from peripheral blood, mainly comprising lymphocytes (T cells, B cells, NK cells) and monocytes. In Clostridium difficile infection (CDI), PBMCs play a key role through immune regulation: T cells (such as Th1/Th17) mediate inflammatory responses, while regulatory T cells (Treg) inhibit excessive immune responses; monocytes differentiate into macrophages and participate in pathogen clearance. PBMCs in CDI patients may show abnormal activation, resulting to cytokine storms (such as increased IL-1β and TNF-α), which are related to the severity of the disease.

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Citation

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Application

  • Human.Clostridioides Difficile Peripheral Blood Mononuclear Cells can be used to study the immunopathological mechanisms associated with Clostridium difficile infection (CDI). It can also be used to test the effects of antibiotics, immunomodulators (such as IL-10, TNF-α inhibitors) or new therapies (such as fecal microbiota transplantation) on immune cell function and evaluate their efficacy and safety. In addition, PBMCs can also be used for biomarker screening.

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