Human Cardiac Myocytes

Description

Human cardiac myocytes are the most energetically active cells in the body. They are highly specialized hyperoxic cells possessing abundant mitochondria. Cardiac myocytes constitute 75% of the heart’s total mass but only about one-third of its total cell count. All cardiac myocytes spontaneously undergo rhythmic membrane depolarization and repolarization. Myocyte contraction is myogenic and independent of neural stimulation.
Human Cardiac Myocytes (HCM) are derived from adult cardiac tissue. After purification, they are cryopreserved and delivered in frozen form. HCM-a cells are identified by immunofluorescence using a sarcomere α-actin-specific antibody. Human Cardiac Myocytes (HCM) have tested negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. However, as these cells do not proliferate in culture, they are not recommended for expansion or long-term culture.

Application

• A complex signaling network within cardiomyocytes regulates the heart’s rhythmic contraction. Cardiomyocyte hypertrophy and apoptosis are pivotal factors contributing to the loss of contractile function in heart failure. An in-depth analysis of these cardiac signaling networks will provide valuable insights into the cellular mechanisms underlying cardiomyocyte death, helping to identify potential therapeutic targets for heart failure.