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Human Choroid Plexus Endothelial Cells

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The choroid plexus plays a wide range of roles in brain development, maturation, aging process, endocrine regulation, and pathogenesis of certain neurodegenerative diseases. The choroid plexuses consist of a single layer of epithelial cells enclosing a vascular core that together form the blood-cerebrospinal fluid barrier. The choroidal capillary is a single layer of endothelial cells […]
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Choroid Plexus Endothelial Cells
Product Code

HCPEC
Species

Human
Cat.No

ABC-TC3567
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Choroid Plexus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells

Description

Human Choroid Plexus Endothelial Cells (HCPEnC) are derived from healthy human brain tissue. Following primary culture, these cells are cryopreserved. Immunofluorescence analysis confirms the expression of endothelial markers PECAM1 and vWF. They also express several tight junction proteins, including ZO-1, OCLN, CLDN1, and CLDN5. Human Choroid Plexus Endothelial Cells form capillary-like structures. In vitro, these cells exhibit limited proliferative capacity and cannot be passaged. Repeated freezing and thawing during culture should be avoided.

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Citation

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Application

  • Human Choroid Plexus Endothelial Cells are valuable tools for advancing the understanding of choroid plexus (CP) organ functions, particularly the complex interactions between endothelial and epithelial cells. Located in the brain’s ventricles, the CP is a highly vascularized structure that forms a critical interface between the cerebrospinal fluid (CSF) and the blood, linking the central nervous system (CNS) with the rest of the body. The endothelial cells within the CP contribute to modulating the blood-CSF barrier (BCSFB), which is essential for maintaining brain homeostasis. Human Choroid Plexus Endothelial Cells serve as in vitro models for studying CP functions and the BCSFB. They are also instrumental in researching disease mechanisms, such as those involved in meningitis, and developing therapeutic approaches targeting these conditions.

Frequently Asked Questions

  • What are Human Choroid Plexus Endothelial Cells?

    Human Choroid Plexus Endothelial Cells are specialized cells lining the blood vessels within the choroid plexus, which plays a critical role in regulating the passage of molecules between the bloodstream and the cerebrospinal fluid (CSF), contributing to brain homeostasis and immune surveillance.

  • How do Human Choroid Plexus Endothelial Cells contribute to the blood-CSF barrier?

    These endothelial cells, together with tight junctions and the surrounding epithelial cells, form part of the blood-CSF barrier. This barrier tightly controls the movement of ions, molecules, and cells between the blood and the cerebrospinal fluid, maintaining a selective permeability crucial for brain health.

  • What makes the permeability of Human Choroid Plexus Endothelial Cells unique?

    Unlike endothelial cells in other parts of the body, Choroid Plexus Endothelial Cells possess unique transporters and low permeability, which ensures the controlled exchange of solutes while preventing harmful substances from entering the cerebrospinal fluid. This specialized permeability is essential for regulating brain fluid dynamics.

  • How are Human Choroid Plexus Endothelial Cells isolated?

    These cells are isolated from the vasculature of the choroid plexus in human brain tissue. Isolation involves precise dissection, followed by enzyme digestion and purification, to obtain a pure population of endothelial cells for in vitro studies.

  • What are the potential applications of Human Choroid Plexus Endothelial Cells in drug discovery?

    These cells are used in drug discovery to screen for compounds that can cross the blood-CSF barrier or modulate its function. They provide a platform for testing drugs aimed at treating neurodegenerative diseases, neuroinflammatory disorders, and conditions affecting cerebrospinal fluid dynamics.

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