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Primary Cells

Human Chronic Lymphoid Leukemia Bone Marrow CD19+ B Cells, Untreated

  • For research use only

Cat No.

ABC-TC3338
Product Type

Immune Cells
Cell Type

B Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Chronic Lymphoid Leukemia
Storage

Liquid Nitrogen

Human CLL Bone Marrow CD19+ B Cells, Untreated enable BCR signaling, immunophenotyping, and drug screening in primary B-cell leukemia research.

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  • Human Chronic Lymphoid Leukemia Bone Marrow CD19+ B Cells, Untreated
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Home | Primary Cells | Human Primary Cells | Immune System Primary Cells | Human Chronic Lymphoid Leukemia Bone Marrow CD19+ B Cells, Untreated

Description

Human Chronic Lymphoid Leukemia Bone Marrow CD19+ B Cells, Untreated are isolated from bone marrow aspirates of untreated CLL patients. These cells represent a purified population of CD19+ B lymphocytes, which are the malignant subset in CLL. Morphologically, CLL B cells are small, mature-appearing lymphocytes with scant cytoplasm and condensed chromatin, typically exhibiting non-adherent, suspension growth in vitro. Karyotype analysis confirms genetic abnormalities associated with CLL, ensuring disease relevance. The cells used are cryopreserved at low passage to maintain physiological characteristics and genetic stability. These cells typically express surface markers such as CD5, CD19, CD20, and CD23. Due to their primary nature, they are non-proliferative in vitro and cannot be subcultured. Repeated freeze-thaw cycles should be avoided to preserve cell viability. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

Human Chronic Lymphoid Leukemia Bone Marrow CD19+ B Cells, Untreated, Human CLL Bone Marrow CD19+ B Cells, CD19+ B Cells, B Cells, CD19+ B Cells, CLL BM CD19+
Species

Human
Cat.No

ABC-TC3338
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

B Cell
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Chronic Lymphoid Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immune Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • These primary CD19+ B cells are ideal for investigating BCR signaling, immune checkpoint regulation, and resistance mechanisms to therapies such as BTK inhibitors. They are also useful in evaluating novel drug responses, profiling gene expression, or modeling tumor-immune microenvironment interactions in CLL. These cells are also employed to investigate interactions with autologous T cells and stromal components within the tumor microenvironment, offering further insights into leukemia treatment research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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