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Human Chronic Lymphoid Leukemia Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory)

  • For research use only

Cat No.

ABC-TC3340
Product Type

Immune Cells
Cell Type

B Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Chronic Lymphoid Leukemia
Storage

Liquid Nitrogen

Human Chronic Lymphoid Leukemia Bone Marrow CD19+/CD5+ B Cells enable immunophenotyping, BCR signaling, and screening in R/R CLL for disease monitoring.

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  • Human Chronic Lymphoid Leukemia Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory)
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Home | Primary Cells | Human Primary Cells | Immune System Primary Cells | Human Chronic Lymphoid Leukemia Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory)

Description

Human Chronic Lymphoid Leukemia (CLL) Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory) are isolated from the bone marrow of CLL patients who have experienced disease relapse or resistance following standard treatments. These cells are a subtype of B lymphocytes, defined by the co-expression of CD19 and CD5 surface markers. The cells are cryopreserved immediately after isolation to retain native phenotypic and functional properties. Functionally, they are involved in aberrant signaling, survival, and proliferation that contribute to disease persistence. These cells are non-adherent and grow in suspension under appropriate culture conditions but are non-proliferative in vitro and cannot be passaged. These cells typically reveal high expression of CD19, CD5, and CD23. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

Human Chronic Lymphoid Leukemia Bone Marrow CD19+/CD5+ B Cells (Relapsed/Refractory), Human CLL Bone Marrow CD19+/CD5+ B Cells, CD19+/CD5+ B Cells, CLL B Cells, CD19+/CD5+ B Cells, CLL BM CD19+/CD5+ (RR)
Species

Human
Cat.No

ABC-TC3340
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

B Cell
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Chronic Lymphoid Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immune Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • These primary CD19+/CD5+ B cells provide a clinically relevant model to study the pathogenesis and treatment resistance mechanisms in relapsed/refractory CLL, making them highly suitable for leukemia surface marker studies. They are particularly valuable for testing novel targeted therapies such as BCL-2 inhibitors, BTK inhibitors, or CAR-T strategies in a patient-specific context. Moreover, they serve as a platform to investigate clonal evolution, apoptosis resistance, and B-cell receptor (BCR) signaling pathways, offering insights that could guide precision medicine approaches in hematological malignancies.These cells are also utilized to assess immune evasion strategies and T cell dysfunction in the CLL microenvironment.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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