Human Chronic Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

Description

Human Chronic Lymphocytic Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are derived from the peripheral blood of newly diagnosed and untreated chronic lymphocytic leukemia (CLL) patients.Common cytogenetic abnormalities include deletion 13q, trisomy 12, deletion 11q, and deletion 17p, detectable by FISH or karyotyping. Morphologically, these cells are mainly mature small lymphocyte-like, with small and round cell bodies. These cells typically express high levels of CD19, CD20 (dim), CD5, and CD23, detectable via flow cytometry.They are tumorigenic and may proliferate in immunodeficient mouse models under specific microenvironmental conditions.Their functional abnormalities are mainly manifested in the continuous activation of the B cell receptor (BCR) signaling pathway, which promotes cell survival; high expression of anti-apoptotic proteins (such as BCL-2 family members), which inhibit programmed cell death; at the same time, abnormal expression of cell adhesion molecules and chemokine receptors, which affects cell homing and tissue infiltration.