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Transfected Stable Cell Lines

Human cKIT (V559D_D820G) BAF3 Cell Line

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Species

Human

Cat.No

ABC-X0381C

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Lymphocytes

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO2

Source Organ

Lymphatic

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

BAF3

Description

Human cKIT (V559D_D820G) BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. cKIT (V559D-D820G) BAF3 overexpression cell line is generated by stable integration of exogenous human cKIT gene containing V559D and D820G mutations into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The V559D and D820G mutations in cKIT enhance kinase activity and are implicated in oncogenesis and resistance to specific inhibitors. These mutations are clinically relevant in gastrointestinal stromal tumors and acute myeloid leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The cKIT (V559D-D820G) BAF3 Overexpression Cell Line serves as a preclinical model for dissecting dual-mutant cKIT function and evaluating next-generation inhibitors.

Inquiring Human cKIT (V559D_D820G) BAF3 Cell Line

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High Viability
To succeed in cell culture
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To support a consistent result
Customization Options
Tailed to your research

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