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Human cKIT (V559D_Y823D) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human cKIT (V559D_Y823D) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0380C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human cKIT (V559D_Y823D) BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. cKIT (V559D_Y823D) BAF3 overexpression cell line is generated by stable integration of an exogenous human cKIT gene harboring V559D and Y823D mutations into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
Mutations in cKIT, a receptor tyrosine kinase, drive constitutive activation of downstream MAPK and PI3K pathways. The V559D and Y823D mutations synergistically promote oncogenic signaling and may influence response to tyrosine kinase inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The cKIT (V559D_Y823D) BAF3 Overexpression Cell Line is a valuable platform for elucidating mutation-specific cKIT signaling and assessing targeted therapeutic responses in hematologic malignancies.

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