For research use only
| Cat No. | ABC-X0303C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Fibroblast |
| Species | Human |
| Host Cell | NIH/3T3 |
| Source Organ | Embryo |
| Disease | Normal |
| Storage | Liquid Nitrogen |
The CLIP1_LTK (G596R) NIH/3T3 Cell Line facilitates investigation of rare CLIP1_LTK mutations in oncogenic signaling and sensitivity to kinase inhibitors.
Human CLIP1_LTK (G596R) NIH/3T3 Cell Line features stable expression of the G596R mutant of the CLIP1_LTK fusion in NIH/3T3 cells. This system supports oncogenicity assays and mechanistic studies of mutation-induced changes in signaling behavior.
Target
The G596R mutation is located in a critical region of the LTK kinase domain and is associated with altered kinase activity and therapeutic resistance. This model allows researchers to examine the structural and functional consequences of this mutation.
AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
| Species | Human |
| Cat.No | ABC-X0303C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO2 |
| Source Organ | Embryo |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | NIH/3T3 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
The cell line is suitable for evaluating mutation-specific drug responses, identifying downstream effectors of G596R signaling, and modeling resistance to LTK-targeted therapies.