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Primary Cells

Human Colonic Epithelial Cells

  • For research use only

Cat No.

ABC-TC3570
Product Type

Intestinal Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Colonic
Disease

Normal
Storage

Liquid Nitrogen

Human colonic epithelial cells are CK20+ E-cadherin+ cells from colon tissue that grow tightly, support barrier, and mediate intestinal immune defense.

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  • Human Colonic Epithelial Cells
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Colonic Epithelial Cells

Description

Human Colonic Epithelial Cells (HCECs) are primary cells isolated from the mucosal lining of the human colon. In vitro, they exhibit characteristic epithelial morphology with well-defined apical brush borders and tight junctions. These cells express key markers including cytokeratin 20 (CK20), villin, and E-cadherin, confirming their intestinal epithelial identity. HCECs play essential roles in nutrient absorption, barrier function, and mucosal immunity, making them invaluable for studying inflammatory bowel disease (IBD), colorectal cancer, and intestinal infections. The cells demonstrate functional electrogenic ion transport and produce mucus secretions when cultured under proper conditions. Within the colonic epithelium, these colon epithelial cells contribute to the integrity of the epithelial system, with the size of epithelial cells reflecting their functional specialization and barrier efficiency. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.

Product Code

HCoEpiC
Species

Human
Cat.No

ABC-TC3570
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Colonic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Intestinal Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results
-Expert teams to provide timely support and assist best experimental outcomes
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Colonic Epithelial Cells can be used to explore the physiological functions of the colon, such as nutrient absorption, mucus secretion, and immune regulation mechanisms, and help to understand the interaction between the intestinal microbiota and the host. These cells can also be used to study inflammatory bowel diseases, colon cancer, and irritable bowel syndrome.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Colonic Epithelial Cells?

    Human Colonic Epithelial Cells are cells that line the inner surface of the colon. They are essential for absorbing water and electrolytes, producing mucus, and forming a barrier against pathogens and toxins.

  • How many times can Human Colonic Epithelial Cells be passaged?

    Human Colonic Epithelial Cells can typically be passaged 3-5 times. However, with each passage, their epithelial characteristics may weaken. Therefore, it is generally recommended to use these cells within three passages to ensure their functionality and reliability in experiments.

  • What are the differences between Human Colonic Epithelial Cells and human intestinal epithelial cells?

    Functionally, Human Colonic Epithelial Cells are specialized for absorbing water and electrolytes, producing mucus, and maintaining colonic health, whereas human intestinal epithelial cells focus more on nutrient absorption and interaction with gut microbiota.

  • How are Human Colonic Epithelial Cells used in drug development and testing?

    Human Colonic Epithelial Cells are utilized in drug development to study drug absorption, metabolism, and toxicity specific to the colonic environment. They help researchers understand how drugs interact with colonic epithelial cells and assess their effectiveness and safety in treating colonic diseases such as ulcerative colitis and colorectal cancer.

  • How are Human Colonic Epithelial Cells obtained?

    Human Colonic Epithelial Cells are isolated from human colonic tissue.

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High Viability
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