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Product Code | HCoEpiC |
Species | Human |
Cat.No | ABC-TC3570 |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Primary Cells |
Size/Quantity | 1 vial |
Cell Type | Epithelial |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Colonic |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Intestinal Cells |
Key Features | -Backed by AcceGen advanced technology |
Human Colonic Epithelial Cells are isolated from human colon tissue. In vitro, the cells grow adherently, exhibit typical epithelial morphology and are closely arranged to form a barrier structure. and are closely arranged to form a barrier structure. Primary human colonic epithelial cells are usually provided at early passages (passage 1–3).Their functions include absorbing nutrients, secreting mucus to lubricate the intestines, transporting waste, and participating in mucosal immune responses, and can identify and eliminate harmful microorganisms and antigens. When the colon is damaged, the cells have the ability to regenerate and can proliferate and differentiate into new epithelial cells to participate in tissue repair.They express epithelial markers such as cytokeratin 20 (CK20) and E-cadherin, which can be detected by immunostaining.
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Human Colonic Epithelial Cells can be used to explore the physiological functions of the colon, such as nutrient absorption, mucus secretion, and immune regulation mechanisms, and help to understand the interaction between the intestinal microbiota and the host. These cells can also be used to study inflammatory bowel diseases, colon cancer, and irritable bowel syndrome.
Human Colonic Epithelial Cells are cells that line the inner surface of the colon. They are essential for absorbing water and electrolytes, producing mucus, and forming a barrier against pathogens and toxins.
Human Colonic Epithelial Cells can typically be passaged 3-5 times. However, with each passage, their epithelial characteristics may weaken. Therefore, it is generally recommended to use these cells within three passages to ensure their functionality and reliability in experiments.
Functionally, Human Colonic Epithelial Cells are specialized for absorbing water and electrolytes, producing mucus, and maintaining colonic health, whereas human intestinal epithelial cells focus more on nutrient absorption and interaction with gut microbiota.
Human Colonic Epithelial Cells are utilized in drug development to study drug absorption, metabolism, and toxicity specific to the colonic environment. They help researchers understand how drugs interact with colonic epithelial cells and assess their effectiveness and safety in treating colonic diseases such as ulcerative colitis and colorectal cancer.