Human Cord Blood CD56+ NK Cells

Description

Human Cord Blood CD56⁺ NK Cells are primary lymphocytes isolated from healthy human umbilical cord blood, characterized by CD56⁺CD3⁻ phenotype and round, non-adherent suspension morphology. They are a key part of innate immunity, capable of recognizing and killing virus-infected and tumor cells without prior sensitization, mainly through perforin and granzyme release. These cells do not proliferate or undergo passaging, requiring liquid nitrogen cryopreservation to maintain functionality. Normal karyotype has been confirmed. Functionally, they also secrete IFN-γ and TNF-α, enhancing inflammatory and adaptive immune responses. They are extensively studied in cancer immunotherapy, infection, immune regulation, and stem cell transplantation research. These cells are particularly valuable for cord blood transplantation studies, offering well-defined cord blood NK cell markers and insights into cord blood cell differentiation for both therapeutic and research applications.

Application

• Human Cord Blood CD56⁺ NK Cells are an ideal source for studying the physiology and cellular characteristics of NK cells in vitro. They can be used to co-culture with other immune cells or study the mechanism of NK cell-mediated cytotoxicity. Natural killer cells are potential candidates for NK cell-based therapy in leukemia and malignancy.