Human dendritic cells (DCs) are specialized antigen-presenting cells derived from peripheral blood of healthy human donors. These cells are critical in initiating adaptive immune responses by activating naïve T cells and promoting their differentiation into effector cells, while also helping to maintain immune tolerance. In culture, human DCs are non-proliferative and survive for up to 7 days as immature dendritic cells (iDCs) when treated with IL-4 and GM-CSF, and can further differentiate into mature dendritic cells with TNF-α and IL-1β. Morphologically, they exhibit dendritic projections and express a characteristic surface marker profile including CD11c⁺, CD86⁺, CD80⁺, HLA-DR⁺, and CD14⁻, confirmed via flow cytometry. While karyotype analysis is not typically performed, they are widely used in cancer immunotherapy, infectious disease models, and autoimmune disorder research due to their potent antigen-presenting capacity and immunomodulatory role. 
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