Human Dopaminergic Neurons (iPSC-derived, Normal)

Description

Human Dopaminergic (DA) Neurons (iPSC-derived, Normal) are terminally differentiated neurons generated from human induced pluripotent stem cells (iPSCs) derived from healthy donors using a defined, reproducible protocol. These neurons exhibit characteristic mature dopaminergic morphology, including extended neurites and phase-bright cell bodies. They express key dopaminergic markers such as tyrosine hydroxylase (TH), dopamine transporter (DAT), FoxA2, and nuclear receptor-related 1 protein (NURR1). Functionally, these cells demonstrate spontaneous electrical activity, synapse formation, and dopamine synthesis. They are ideal for modeling neurological diseases, neurotoxicity screening, drug discovery, and research focused on Parkinson’s disease and other neurodegenerative disorders. As fully differentiated iPSC derived neurons, they provide a stable and physiologically relevant platform for human neurobiology studies.

Application

• Human iPSC-derived Dopaminergic Neurons are suitable for studying protein dynamics in dopaminergic neurons. Due to their complex functions, high heterogeneity, and involvement in various neural processes, these cells offer a robust in vitro model for dopaminergic neuron proteomics. Additionally, they are ideal for modeling neurodegenerative diseases such as Parkinson’s disease, helping to investigate disease pathogenesis and discover new therapeutic targets.