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Species | Human |
Cat.No | ABC-X0343C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Fibroblast |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Embryo |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | NIH/3T3 |
Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Overexpression Cell Line is an engineered NIH/3T3 model harboring dual EML4-ALK mutations (C1156Y and G1296A) introduced via lentiviral transduction. Expression is confirmed by qRT-PCR, and cells are cultured below passage 20.
Target
C1156Y and G1296A are compound ALK mutations that confer broad resistance to ALK inhibitors, complicating targeted therapy for ALK-rearranged lung cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only