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Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0343C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Overexpression Cell Line is an engineered NIH/3T3 model harboring dual EML4-ALK mutations (C1156Y and G1296A) introduced via lentiviral transduction. Expression is confirmed by qRT-PCR, and cells are cultured below passage 20.
Target
C1156Y and G1296A are compound ALK mutations that confer broad resistance to ALK inhibitors, complicating targeted therapy for ALK-rearranged lung cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model aids in studying resistance evolution under selective ALK TKI pressure and supports drug screening for therapies effective against compound ALK mutations.

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