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Transfected Stable Cell Lines

Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line

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Species

Human

Cat.No

ABC-X0343C

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Fibroblast

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO2

Source Organ

Embryo

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

NIH/3T3

Description

Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Overexpression Cell Line is an engineered NIH/3T3 model harboring dual EML4-ALK mutations (C1156Y and G1296A) introduced via lentiviral transduction. Expression is confirmed by qRT-PCR, and cells are cultured below passage 20.
Target
C1156Y and G1296A are compound ALK mutations that confer broad resistance to ALK inhibitors, complicating targeted therapy for ALK-rearranged lung cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • This model aids in studying resistance evolution under selective ALK TKI pressure and supports drug screening for therapies effective against compound ALK mutations.

Inquiring Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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