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Transfected Stable Cell Lines

Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line

  • For research use only

Cat No.

ABC-X0343C
Product Type

Overexpression Stable Cell Lines
Cell Type

Fibroblast
Species

Human
Host Cell

NIH/3T3
Source Organ

Embryo
Disease

Normal
Storage

Liquid Nitrogen

Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line enables assessment of resistance mutations to ALK inhibitors and their effect on cell signaling.

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  • Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Cell Line

Description

Human EML4_ALK (C1156Y_G1296A) NIH/3T3 Overexpression Cell Line is an engineered NIH/3T3 model harboring dual EML4-ALK mutations (C1156Y and G1296A) introduced via lentiviral transduction. Expression is confirmed by qRT-PCR, and cells are cultured below passage 20.
Target
C1156Y and G1296A are compound ALK mutations that confer broad resistance to ALK inhibitors, complicating targeted therapy for ALK-rearranged lung cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0343C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Application

  • For research use only

  • This model aids in studying resistance evolution under selective ALK TKI pressure and supports drug screening for therapies effective against compound ALK mutations.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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