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Human EML4_ALK (F1174C_G1202R) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (F1174C_G1202R) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0341C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human EML4_ALK (F1174C_G1202R) NIH/3T3 Overexpression Cell Line is derived from NIH/3T3 fibroblasts and engineered to stably express a dual-mutant EML4-ALK fusion gene with F1174C and G1202R alterations via lentiviral transduction. Validation is performed using qRT-PCR, and cells are maintained below passage 20.
Target
The EML4-ALK fusion is a hallmark driver in ALK-positive NSCLC. The F1174C and G1202R mutations confer resistance to multiple ALK inhibitors, including lorlatinib. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model supports mechanistic studies of ALK inhibitor resistance and provides a high-value platform for developing next-generation ALK-targeted therapeutics.

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