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Species | Human |
Cat.No | ABC-X0341C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Fibroblast |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Embryo |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | NIH/3T3 |
Human EML4_ALK (F1174C_G1202R) NIH/3T3 Overexpression Cell Line is derived from NIH/3T3 fibroblasts and engineered to stably express a dual-mutant EML4-ALK fusion gene with F1174C and G1202R alterations via lentiviral transduction. Validation is performed using qRT-PCR, and cells are maintained below passage 20.
Target
The EML4-ALK fusion is a hallmark driver in ALK-positive NSCLC. The F1174C and G1202R mutations confer resistance to multiple ALK inhibitors, including lorlatinib. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only