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Transfected Stable Cell Lines

Human EML4_ALK (F1174C_G1202R) NIH/3T3 Cell Line

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Species

Human

Cat.No

ABC-X0341C

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Fibroblast

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO2

Source Organ

Embryo

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

NIH/3T3

Description

Human EML4_ALK (F1174C_G1202R) NIH/3T3 Overexpression Cell Line is derived from NIH/3T3 fibroblasts and engineered to stably express a dual-mutant EML4-ALK fusion gene with F1174C and G1202R alterations via lentiviral transduction. Validation is performed using qRT-PCR, and cells are maintained below passage 20.
Target
The EML4-ALK fusion is a hallmark driver in ALK-positive NSCLC. The F1174C and G1202R mutations confer resistance to multiple ALK inhibitors, including lorlatinib. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • This model supports mechanistic studies of ALK inhibitor resistance and provides a high-value platform for developing next-generation ALK-targeted therapeutics.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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