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Transfected Stable Cell Lines

Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0287C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line is engineered to study ALK fusion double mutations’ effects on lung cancer growth and drug resistance.

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  • Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line

Description

Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line is derived from murine Ba/F3 cells with lentiviral transduction of the human EML4-ALK fusion gene carrying F1174L and G1202R double mutations. Cells are expanded below passage 20 and validated by qRT-PCR.
Target
The EML4-ALK fusion is a potent oncogenic driver in lung cancer. F1174L and G1202R mutations co-occur within the ALK kinase domain, conferring strong resistance to first- and second-generation ALK inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0287C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line supports investigation of compound ALK inhibitor resistance, kinase structural modeling, and testing of third-generation ALK inhibitors.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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