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Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0287C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human EML4_ALK (F1174L_G1202R) BAF3 Cell Line is derived from murine Ba/F3 cells with lentiviral transduction of the human EML4-ALK fusion gene carrying F1174L and G1202R double mutations. Cells are expanded below passage 20 and validated by qRT-PCR.
Target
The EML4-ALK fusion is a potent oncogenic driver in lung cancer. F1174L and G1202R mutations co-occur within the ALK kinase domain, conferring strong resistance to first- and second-generation ALK inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line supports investigation of compound ALK inhibitor resistance, kinase structural modeling, and testing of third-generation ALK inhibitors.

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