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Species | Human |
Cat.No | ABC-X0342C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Fibroblast |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Embryo |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | NIH/3T3 |
Human EML4_ALK (L1196M_D1203N) NIH/3T3 Overexpression Cell Line is a lentivirally transduced NIH/3T3 model expressing a dual-mutant EML4-ALK fusion gene containing L1196M and D1203N substitutions. Cells are verified by qRT-PCR and preserved under low passage conditions.
Target
L1196M (gatekeeper) and D1203N mutations within the ALK kinase domain are associated with potent resistance to first- and second-generation ALK inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only