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Transfected Stable Cell Lines

Human EML4_ALK (L1196M_D1203N) NIH/3T3 Cell Line

  • For research use only

Cat No.

ABC-X0342C
Product Type

Overexpression Stable Cell Lines
Cell Type

Fibroblast
Species

Human
Host Cell

NIH/3T3
Source Organ

Embryo
Disease

Normal
Storage

Liquid Nitrogen

Human EML4_ALK (L1196M_D1203N) NIH/3T3 Cell Line supports investigation of compound ALK mutations and their impact on targeted therapy efficacy.

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  • Human EML4_ALK (L1196M_D1203N) NIH/3T3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (L1196M_D1203N) NIH/3T3 Cell Line

Description

Human EML4_ALK (L1196M_D1203N) NIH/3T3 Overexpression Cell Line is a lentivirally transduced NIH/3T3 model expressing a dual-mutant EML4-ALK fusion gene containing L1196M and D1203N substitutions. Cells are verified by qRT-PCR and preserved under low passage conditions.
Target
L1196M (gatekeeper) and D1203N mutations within the ALK kinase domain are associated with potent resistance to first- and second-generation ALK inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0342C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Application

  • For research use only

  • This cell line provides a robust system for modeling compound ALK resistance mutations and evaluating next-generation inhibitors under clinically relevant conditions.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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