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Human EML4_ALK (L1196M_D1203N) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human EML4_ALK (L1196M_D1203N) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0342C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human EML4_ALK (L1196M_D1203N) NIH/3T3 Overexpression Cell Line is a lentivirally transduced NIH/3T3 model expressing a dual-mutant EML4-ALK fusion gene containing L1196M and D1203N substitutions. Cells are verified by qRT-PCR and preserved under low passage conditions.
Target
L1196M (gatekeeper) and D1203N mutations within the ALK kinase domain are associated with potent resistance to first- and second-generation ALK inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line provides a robust system for modeling compound ALK resistance mutations and evaluating next-generation inhibitors under clinically relevant conditions.

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