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Transfected Stable Cell Lines

Human ERBB2 (G776S) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (G776S) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0036C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (G776S) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. ERBB2 (G776S) BAF3 mutant cell line is generated by stable integration of exogenous human ERBB2 gene harboring the G776S mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
ERBB2 (HER2) is a receptor tyrosine kinase involved in the regulation of cell growth and differentiation through PI3K/AKT and MAPK pathways. The G776S mutation, located in the kinase domain, leads to constitutive activation of ERBB2 and has been associated with increased oncogenic potential and resistance to targeted therapies. AcceGen offers generation of stable overexpression and point-mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The ERBB2 (G776S) BAF3 Cell Line serves as an effective platform to investigate HER2-driven oncogenic signaling, drug resistance, and responsiveness to HER2-targeted inhibitors. This model is widely applicable for functional genomics, biomarker analysis, and therapeutic screening in precision oncology.

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