For research use only
| Cat No. | ABC-X0196C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Lymphocytes |
| Species | Human |
| Host Cell | BAF3 |
| Source Organ | Lymphatic |
| Disease | Normal |
| Storage | Liquid Nitrogen |
The human ERBB2 (S310F) BAF3 Cell Line models HER2 point mutation for mechanistic cancer studies and therapeutic screening of HER2-targeted drugs.
Human ERBB2 (S310F) BAF3 Cell Line is a stable Ba/F3 cell line expressing human ERBB2 with the activating S310F mutation. Lentiviral transduction ensures stable integration, with transgene expression validated by qRT-PCR. Cells are cultured under passage 20.
Target
ERBB2 (HER2) S310F is a hotspot mutation in the extracellular domain that promotes ligand-independent dimerization and downstream signaling. It is implicated in lung, breast, and bladder cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
| Species | Human |
| Cat.No | ABC-X0196C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocytes |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO2 |
| Source Organ | Lymphatic |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | BAF3 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
This model is ideal for studying ERBB2-driven oncogenesis, therapeutic response to HER2-targeted drugs, and mutation-specific signaling dynamics.