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Transfected Stable Cell Lines

Human ERBB2 (S310Y) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (S310Y) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0197C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (S310Y) BAF3 Cell Line is a stable Ba/F3 cell line modified to express the human ERBB2 S310Y variant. Stable expression is achieved through lentiviral vector transduction and confirmed by qRT-PCR. Cell line passage is restricted to <P20. Target The ERBB2 S310Y mutation confers constitutive activation and is linked to resistance against certain HER2 inhibitors. It activates downstream PI3K/AKT and MAPK pathways in oncogenesis. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model enables evaluation of HER2-targeted therapies, including antibody-drug conjugates and TKIs, and is applicable for dissecting mutant-specific resistance pathways.

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