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Transfected Stable Cell Lines

Human ERBB2 (V659D) BAF3 Cell Line

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Species

Human

Cat.No

ABC-X0065C

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Lymphocyte

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO₂

Source Organ

Lymphatic

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

BAF3

Description

Human ERBB2 (V659D) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. The mutant cell line expresses human ERBB2 gene containing the V659D point mutation, introduced via lentiviral transduction.
Target
ERBB2 (also known as HER2) is a receptor tyrosine kinase involved in regulating cell growth and differentiation. The V659D mutation, located in the transmembrane domain, leads to constitutive dimerization and activation, driving oncogenic signaling through MAPK and PI3K/AKT pathways. This variant is relevant in breast and lung cancers. AcceGen offers ERBB2 mutant cell models for oncogenic mechanism research and drug screening. Polyclonal or monoclonal is optional.

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Application

  • For research use only

  • The ERBB2 (V659D) BAF3 Cell Line enables analysis of ligand-independent HER2 signaling, oncogenic transformation, and therapeutic intervention using HER2-targeted agents including tyrosine kinase inhibitors and monoclonal antibodies.

Inquiring Human ERBB2 (V659D) BAF3 Cell Line

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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