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Transfected Stable Cell Lines

Human ERBB2 (V659D) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0065C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The human ERBB2 (V659D) BAF3 cell line provides an ideal model for studying HER2 mutations and their role in tumors, supporting the development.

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  • Human ERBB2 (V659D) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (V659D) BAF3 Cell Line

Description

Human ERBB2 (V659D) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. The mutant cell line expresses human ERBB2 gene containing the V659D point mutation, introduced via lentiviral transduction.
Target
ERBB2 (also known as HER2) is a receptor tyrosine kinase involved in regulating cell growth and differentiation. The V659D mutation, located in the transmembrane domain, leads to constitutive dimerization and activation, driving oncogenic signaling through MAPK and PI3K/AKT pathways. This variant is relevant in breast and lung cancers. AcceGen offers ERBB2 mutant cell models for oncogenic mechanism research and drug screening. Polyclonal or monoclonal is optional.

Species

Human
Cat.No

ABC-X0065C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The ERBB2 (V659D) BAF3 Cell Line enables analysis of ligand-independent HER2 signaling, oncogenic transformation, and therapeutic intervention using HER2-targeted agents including tyrosine kinase inhibitors and monoclonal antibodies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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