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Transfected Stable Cell Lines

Human ERBB2 (V777L) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (V777L) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0004C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (V777L) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. ERBB2 (V777L) BAF3 mutant cell line is generated by stable integration of exogenous human ERBB2 gene harboring the V777L point mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
The ERBB2 (HER2) gene encodes a receptor tyrosine kinase that belongs to the EGFR family and plays a pivotal role in regulating cell growth and differentiation. The V777L mutation, located in the kinase domain, is a known gain-of-function alteration that promotes constitutive ERBB2 activation and downstream oncogenic signaling via the PI3K/AKT and MAPK pathways. This mutation has been identified in various cancer types, including breast and lung cancer, and is associated with resistance to some EGFR inhibitors. AcceGen offers generation of stable mutation-specific or overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The ERBB2 (V777L) BAF3 Cell Line serves as a powerful tool to investigate ERBB2-driven oncogenic mechanisms and therapeutic interventions. This model enables mechanistic studies of constitutive HER2 activation, IL-3-independent proliferation, and response to targeted inhibitors. It is utilized for high-throughput screening of ERBB2-targeted agents, including small-molecule kinase inhibitors and monoclonal antibodies.

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