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Transfected Stable Cell Lines

Human ERBB2 (V842I) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0001C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The human ERBB2 (V842I) BAF3 cell line provides a powerful tool for studying tumor biology and therapeutic interventions, helping to reveal the mechanisms.

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  • Human ERBB2 (V842I) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (V842I) BAF3 Cell Line

Description

Human ERBB2 (V842I) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. ERBB2 (V842I) BAF3 mutant cell line is generated by stable integration of exogenous human ERBB2 (V842I) gene into Ba/F3 host cells using our optimized transduction of lentiviral vectors. The expression cassette contains the full-length ERBB2 open reading frame harboring the clinically relevant V842I point mutation.
Target
The ERBB2 (HER2) gene encodes a transmembrane receptor tyrosine kinase belonging to the EGFR family. The V842I mutation, located within the kinase domain, leads to constitutive activation of downstream oncogenic pathways including PI3K/AKT and MAPK. This gain-of-function mutation has been implicated in tumorigenesis and drug resistance in multiple cancer types such as lung adenocarcinoma and breast carcinoma. ERBB2 (V842I) serves as a potential therapeutic target due to its role in promoting cell proliferation and survival independent of ligand binding. AcceGen offers generation of stable mutation-specific or overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0001C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The ERBB2 (V842I) BAF3 Cell Line serves as a powerful tool to investigate ERBB2-driven oncogenic mechanisms and therapeutic interventions. This model enables mechanistic studies of kinase domain mutations, IL-3-independent proliferation, and drug resistance in hematopoietic and solid tumor models. It is utilized for high-throughput screening of ERBB2-targeted inhibitors, including irreversible kinase inhibitors and antibody-based therapeutics.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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