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Transfected Stable Cell Lines

Human ERBB2_PDL1 MC38 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2_PDL1 MC38 Cell Line
Species

Human
Cat.No

ABC-X0139C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Colon
Disease

Colon Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MC38

Description

Human ERBB2_PDL1 MC38 Cell Line is a stable murine colon adenocarcinoma model derived from MC38 cells, engineered via lentiviral transduction to co-express human ERBB2 and PDL1 genes. The expression of both transgenes is confirmed by qRT-PCR, and cells are maintained under low passage conditions (<P20). Target ERBB2 (HER2) is a receptor tyrosine kinase implicated in tumorigenesis via PI3K/AKT and MAPK signaling, while PDL1 mediates immune evasion through PD-1 binding. Their co-expression models tumor-immune interaction and resistance to immunotherapy. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model is suitable for studying ERBB2-driven oncogenesis and immune checkpoint blockade strategies. It facilitates dual-targeted therapy development and functional assays involving tumor-immune dynamics.

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