Human Esophageal Cancer Peripheral Blood Mononuclear Cells

Description

Human Esophageal Cancer Peripheral Blood Mononuclear Cells (PBMCs) are isolated from patients with histologically confirmed esophageal squamous cell carcinoma (ESCC) or adenocarcinoma (EAC), two distinct malignancies with different etiologies and immune profiles. These human-derived PBMCs contain immune cell populations (T cells, B cells, NK cells, monocytes) that demonstrate esophageal cancer-specific alterations, including increased exhausted PD-1⁺/TIM-3⁺ T cells, elevated Tregs (CD4⁺CD25⁺FoxP3⁺), and tumor-educated myeloid cells. The cells exhibit typical mononuclear morphology with intact surface markers and maintain functional cytokine production (IL-6, IL-10, TGF-β) characteristic of the immunosuppressive tumor microenvironment. They are particularly valuable for studying the distinct immunobiology of ESCC (associated with smoking/alcohol) versus EAC (associated with Barrett’s esophagus). These PBMCs are essential for PBMC isolation esophageal cancer, enabling studies of immune modulation in esophageal cancer and characterization of the systemic immune response in esophageal cancer.