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Transfected Stable Cell Lines

Human FGFR2 (C382R) BAF3 Cell Line

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Species

Human

Cat.No

ABC-X0088C

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Lymphocyte

Shipping Info

Dry Ice

Growth Conditions

37 °C, 5% CO₂

Source Organ

Lymphatic

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Overexpression Stable Cell Lines

Host Cell

BAF3

Description

Human FGFR2 (C382R) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FGFR2 (C382R) BAF3 mutant cell line is generated by stable integration of exogenous human FGFR2 gene harboring the C382R mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
FGFR2 encodes a receptor tyrosine kinase essential for development and cellular homeostasis. The C382R mutation occurs in the extracellular domain and induces ligand-independent receptor dimerization and constitutive activation, promoting tumorigenic signaling. It has been identified in intrahepatic cholangiocarcinoma and endometrial carcinoma. AcceGen offers generation of stable mutant cell lines with defined oncogenic alterations. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The FGFR2 (C382R) BAF3 Cell Line serves as a powerful tool to investigate aberrant FGFR2 signaling and therapeutic intervention. This model supports IL-3-independent proliferation, allowing assessment of FGFR-targeted therapies and resistance mechanisms. It is utilized in pathway dissection and personalized drug screening in oncology research.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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