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Human FGFR2 (E565G) BICC1 BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR2 (E565G) BICC1 BAF3 Cell Line
Species

Human
Cat.No

ABC-X0015C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The FGFR2 (E565G) BICC1 BAF3 Cell Line is engineered by introducing the human FGFR2-BICC1 fusion gene containing an E565G activating mutation into BAF3 cells via lentiviral vectors. The E565G mutation enhances FGFR2 kinase activity and oncogenic transformation.
Target
FGFR2-BICC1 fusions are recurrent in intrahepatic cholangiocarcinoma. The E565G mutation within the kinase domain enhances ligand-independent activation and promotes oncogenic signaling. This model facilitates study of FGFR2 fusion-driven carcinogenesis and drug responses. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line supports high-throughput screening of FGFR inhibitors, biomarker discovery, and validation of therapeutic agents targeting FGFR2 alterations in liver and bile duct cancers. It is suitable for mechanistic pathway analysis and resistance profiling.

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