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Transfected Stable Cell Lines

Human FGFR2 (E565G) BICC1 BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0015C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

This cell line models the FGFR2-BICC1 (E565G) fusion mutation to support drug screening and functional analysis in FGFR2-driven tumor studies.

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  • Human FGFR2 (E565G) BICC1 BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR2 (E565G) BICC1 BAF3 Cell Line

Description

The FGFR2 (E565G) BICC1 BAF3 Cell Line is engineered by introducing the human FGFR2-BICC1 fusion gene containing an E565G activating mutation into BAF3 cells via lentiviral vectors. The E565G mutation enhances FGFR2 kinase activity and oncogenic transformation.
Target
FGFR2-BICC1 fusions are recurrent in intrahepatic cholangiocarcinoma. The E565G mutation within the kinase domain enhances ligand-independent activation and promotes oncogenic signaling. This model facilitates study of FGFR2 fusion-driven carcinogenesis and drug responses. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0015C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line supports high-throughput screening of FGFR inhibitors, biomarker discovery, and validation of therapeutic agents targeting FGFR2 alterations in liver and bile duct cancers. It is suitable for mechanistic pathway analysis and resistance profiling.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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