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Human FGFR3 (G375C) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR3 (G375C) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0026C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human FGFR3 (G375C) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FGFR3 (G375C) BAF3 mutant cell line is generated by stable integration of exogenous human FGFR3 gene harboring the G375C point mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
FGFR3 encodes a receptor tyrosine kinase involved in skeletal development and cell signaling. The G375C mutation is located in the extracellular domain and promotes ligand-independent dimerization, contributing to constitutive activation. Such mutations are associated with skeletal dysplasia and cancers such as bladder carcinoma. AcceGen offers generation of stable overexpression and mutant-specific cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

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Application

  • For research use only

  • The FGFR3 (G375C) BAF3 Cell Line serves as a powerful tool to investigate aberrant FGFR3 activation and its impact on oncogenic signaling. This model enables mechanistic studies of FGFR3-induced transformation, ERK/MAPK pathway activation, and evaluation of FGFR inhibitors. It is utilized for drug screening and validation of FGFR3-targeted therapies.

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