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Human FLT3 (ITD_N701K) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FLT3 (ITD_N701K) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0032C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human FLT3 (ITD_N701K) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FLT3 (ITD_N701K) BAF3 mutant cell line is generated by stable integration of exogenous human FLT3 gene harboring internal tandem duplication (ITD) and N701K mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
FLT3 is a receptor tyrosine kinase involved in hematopoietic stem cell proliferation and survival. The ITD and N701K mutations result in ligand-independent dimerization and constitutive activation of FLT3 signaling, driving leukemogenesis. These mutations are frequently identified in acute myeloid leukemia (AML) and are associated with poor prognosis and therapy resistance. AcceGen offers generation of stable overexpression and multi-mutation models for targeted research applications. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The FLT3 (ITD_N701K) BAF3 Cell Line serves as a powerful model to investigate dual-mutant FLT3 signaling in hematologic malignancies. This platform enables evaluation of FLT3 inhibitor efficacy, resistance mechanisms, and pathway-specific combination treatments in preclinical drug discovery settings.

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