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Species | Human |
Cat.No | ABC-X0027C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Lymphocytes |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Lymphatic |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | BAF3 |
The GOPC ROS1 BAF3 Cell Line expresses the human GOPC-ROS1 fusion protein via lentiviral integration. This fusion combines the coiled-coil domain of GOPC with the kinase domain of ROS1, leading to constitutive kinase activation.
Target
GOPC-ROS1 fusion is identified in glioblastoma and other solid tumors. The fusion results in ligand-independent ROS1 activation, triggering downstream MAPK and JAK/STAT pathways. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only