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Transfected Stable Cell Lines

Human GOPC ROS1 BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human GOPC ROS1 BAF3 Cell Line
Species

Human
Cat.No

ABC-X0027C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The GOPC ROS1 BAF3 Cell Line expresses the human GOPC-ROS1 fusion protein via lentiviral integration. This fusion combines the coiled-coil domain of GOPC with the kinase domain of ROS1, leading to constitutive kinase activation.
Target
GOPC-ROS1 fusion is identified in glioblastoma and other solid tumors. The fusion results in ligand-independent ROS1 activation, triggering downstream MAPK and JAK/STAT pathways. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model supports research into ROS1-driven tumorigenesis, drug development for fusion-positive tumors, and resistance mechanism evaluation.

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