Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells

Description

Human Hepatitis C Virus (HCV) Peripheral Blood Mononuclear Cells (PBMCs) are mainly derived from the peripheral blood of HCV-infected patients. HCV invades cells by binding to receptors such as CD81 and SR-BI on the surface of PBMCs through the envelope glycoprotein E1/E2, replicates at a low level in the cytoplasm, and forms a persistent infection reservoir. Mononuclear cells with round lymphocytes and monocytes; typically non-adherent, suspension growthHCV replication in PBMC can escape immune surveillance and lead to chronic inflammatory response. Chronic HCV infection can cause cirrhosis and hepatocellular carcinoma, and is associated with neurocognitive dysfunction, which may be related to the potential invasion of the virus on the central nervous system and PBMC-mediated immune activation. Persistent HCV infection reservoir in PBMCs; immune evasion through viral replication; associated with systemic effects like cirrhosis, hepatocellular carcinoma, and neurocognitive dysfunction through immune activation.