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Transfected Stable Cell Lines

Human IL7Ra_CRLF2 BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0236C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human IL7Ra_CRLF2 BAF3 Cell Line enables functional studies of cytokine receptor complexes in hematopoietic cell signaling and leukemia progression.

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  • Human IL7Ra_CRLF2 BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human IL7Ra_CRLF2 BAF3 Cell Line

Description

Human IL7Ra_CRLF2 BAF3 Cell Line is a genetically engineered model derived from murine BAF3 cells based on customers’ requirement. The cell line is generated by stable co-expression of human IL7Ra and CRLF2 in BAF3 host cells using our optimized lentiviral transduction protocol. Edited cells are maintained at low passage numbers (<P20) and validated by qRT-PCR. Target IL7Ra and CRLF2 form a receptor heterodimer that activates JAK-STAT signaling in response to thymic stromal lymphopoietin (TSLP). Their co-overexpression is implicated in Ph-like acute lymphoblastic leukemia (ALL), promoting leukemogenesis through cytokine signaling dysregulation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Species

Human
Cat.No

ABC-X0236C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This dual overexpression cell line facilitates investigation of the IL7Ra/CRLF2 axis in hematological malignancies, allowing drug screening and pathway analysis of JAK inhibitors, cytokine modulators, and downstream transcriptional effects.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
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