Human Iris Pigment Epithelial Cells

Description

Human Iris Pigment Epithelial Cells (HIPEpiC) are primary epithelial cells isolated from the posterior pigmented layer of the human iris. Morphologically cuboidal and pigmented, HIPEpiC demonstrate stable adherent growth mode under defined conditions. HIPEpiC share several functional similarities with retinal pigment epithelial cells, including phagocytosis of photoreceptor outer segments and secretion of trophic factors such as VEGF and PEDF. They contribute to ocular immune privilege and homeostasis by modulating inflammatory responses and suppressing T cell activation via CD86–CTLA-4 interaction. In transplantation models, HIPEpiC integrate with native retinal tissue and exhibit survival capacity within the subretinal space, indicating their regenerative potential. Each lot undergoes rigorous screening and isolation procedures and is tested to ensure it is free from contamination by HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.