Human Trabecular Meshwork Cells

Description

Human Trabecular Meshwork Cells (HTMCs) are derived from the trabecular meshwork (TM). These cells are primarily of mesenchymal origin and exhibit heterogeneous morphology, reflecting their dynamic role in maintaining aqueous humor outflow. HTM cells display distinct ultrastructural features, such as elongated processes, abundant rough endoplasmic reticulum, and Golgi apparatus, indicative of their secretory and phagocytic functions. These cells regulate aqueous humor drainage by modulating ECM turnover and contractility, thereby maintaining intraocular pressure (IOP) homeostasis. Key molecular markers expressed by HTM cells include α-smooth muscle actin (α-SMA) and fibronectin. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.