Human Kidney Cancer Peripheral Blood Mononuclear Cells

Description

Human Kidney Cancer Peripheral Blood Mononuclear Cells (PBMCs) are isolated from peripheral blood of patients with histologically confirmed renal cell carcinoma (RCC), representing clear cell, papillary, and chromophobe subtypes. These human-derived PBMCs contain immune cell populations (T cells, B cells, NK cells, monocytes) that exhibit RCC-specific immune alterations, including elevated exhausted PD-1⁺CD8⁺ T cells, increased Treg populations (CD4⁺CD25⁺FoxP3⁺), and tumor-associated macrophages (CD163⁺). The cells display typical mononuclear morphology with intact surface markers and maintain functional cytokine production (IFN-γ, IL-10, VEGF) characteristic of RCC’s highly vascularized microenvironment. They are particularly valuable for studying the immunobiology of kidney cancer, which shows unique sensitivity to immunotherapy despite low mutational burden. These PBMCs are essential for assessing inflammation markers in kidney cancer, investigating adaptive immunity in kidney cancer, performing detailed PBMC profiling kidney cancer, and understanding the overall renal cell carcinoma immune response.