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Species | Human |
Cat.No | ABC-X0337C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Lymphocytes |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Lymphatic |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | BAF3 |
Human KIF5B_RET (L730Q) BAF3 Overexpression Cell Line is a lentivirally modified Ba/F3 model expressing the oncogenic KIF5B_RET fusion containing the L730Q mutation. The cells are validated by qRT-PCR and cultured below passage 20.
Target
The KIF5B_RET fusion leads to constitutive RET kinase activity, while the L730Q mutation is linked to enhanced oncogenic signaling and potential resistance to RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only