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Human KIF5B_RET (L730Q) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (L730Q) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0337C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (L730Q) BAF3 Overexpression Cell Line is a lentivirally modified Ba/F3 model expressing the oncogenic KIF5B_RET fusion containing the L730Q mutation. The cells are validated by qRT-PCR and cultured below passage 20.
Target
The KIF5B_RET fusion leads to constitutive RET kinase activity, while the L730Q mutation is linked to enhanced oncogenic signaling and potential resistance to RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line serves as a preclinical model for dissecting RET-driven oncogenesis and for screening RET-targeted therapies, particularly against resistant mutations.

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