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Transfected Stable Cell Lines

Human KIF5B_RET (L730Q) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0337C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human KIF5B_RET (L730Q) BAF3 Cell Line enables functional analysis of RET fusions in tumorigenic transformation and RET-targeted drug screening.

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  • Human KIF5B_RET (L730Q) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (L730Q) BAF3 Cell Line

Description

Human KIF5B_RET (L730Q) BAF3 Overexpression Cell Line is a lentivirally modified Ba/F3 model expressing the oncogenic KIF5B_RET fusion containing the L730Q mutation. The cells are validated by qRT-PCR and cultured below passage 20.
Target
The KIF5B_RET fusion leads to constitutive RET kinase activity, while the L730Q mutation is linked to enhanced oncogenic signaling and potential resistance to RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0337C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line serves as a preclinical model for dissecting RET-driven oncogenesis and for screening RET-targeted therapies, particularly against resistant mutations.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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