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Human KRAS (G12C_A59S) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KRAS (G12C_A59S) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0277C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KRAS (G12C_A59S) BAF3 Cell Line is a genetically engineered model derived from murine pro-B Ba/F3 parental cells based on customers’ requirement. KRAS (G12C_A59S) BAF3 overexpression cell line is generated by stable integration of exogenous human KRAS carrying dual G12C and A59S mutations into Ba/F3 host cells using lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
KRAS encodes a GTPase functioning in the RAS/MAPK pathway to regulate cell growth and survival. The G12C and A59S mutations confer constitutive activity and altered effector binding, contributing to tumorigenesis in non-small cell lung and colorectal cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The KRAS (G12C_A59S) BAF3 Cell Line is used to investigate mechanisms of KRAS mutation synergy, resistance to KRAS-G12C inhibitors, and combinatorial therapeutic strategies. It is ideal for high-throughput screening and mechanistic studies of mutant RAS isoforms in cancer progression.

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