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Transfected Stable Cell Lines

Human KRAS (G12C_A59S) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0277C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human KRAS (G12C_A59S) BAF3 Cell Line is developed to study KRAS double mutations’ effects on cancer cell signaling and drug resistance mechanisms.

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  • Human KRAS (G12C_A59S) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KRAS (G12C_A59S) BAF3 Cell Line

Description

Human KRAS (G12C_A59S) BAF3 Cell Line is a genetically engineered model derived from murine pro-B Ba/F3 parental cells based on customers’ requirement. KRAS (G12C_A59S) BAF3 overexpression cell line is generated by stable integration of exogenous human KRAS carrying dual G12C and A59S mutations into Ba/F3 host cells using lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
KRAS encodes a GTPase functioning in the RAS/MAPK pathway to regulate cell growth and survival. The G12C and A59S mutations confer constitutive activity and altered effector binding, contributing to tumorigenesis in non-small cell lung and colorectal cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0277C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The KRAS (G12C_A59S) BAF3 Cell Line is used to investigate mechanisms of KRAS mutation synergy, resistance to KRAS-G12C inhibitors, and combinatorial therapeutic strategies. It is ideal for high-throughput screening and mechanistic studies of mutant RAS isoforms in cancer progression.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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