Human Monocyte-Derived Dendritic Cells

Description

Human Monocyte-Derived Dendritic Cells (monocyte derived dendritic cells) are professional antigen-presenting cells generated through in vitro differentiation of CD14⁺ monocytes isolated from human peripheral blood. These immunologically potent cells exhibit characteristic dendritic morphology with extensive membrane projections and express key surface markers including CD1a, CD11c, HLA-DR, and co-stimulatory molecules CD80/CD86, which are essential for their role in T cell activation and immune response modulation. moDCs play a pivotal role in bridging innate and adaptive immunity by efficiently capturing, processing, and presenting antigens to naïve T cells, making them invaluable for studying infectious diseases, cancer immunotherapy, and autoimmune disorders. These primary dendritic cells are generated following a standardized monocyte-derived dendritic cells protocol and are characterized using human dendritic cell markers or human DC markers to ensure consistent functionality and identity. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria, while maintaining full functional capacity for antigen uptake and presentation.

Application

• Human Monocyte-Derived Dendritic Cells can be used in tumor immunotherapy, vaccine development, infectious disease research, and exploration of the mechanisms of autoimmune diseases. In addition, in viral infection research, these cells can simulate the interaction between pathogens and the innate immune system, providing a model for vaccine adjuvant screening and antiviral drug evaluation.