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Transfected Stable Cell Lines

Human MPL (W515K) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0359C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human MPL (W515K) BAF3 Cell Line, MPL, BAF3, Overexpression Stable Cell Lines, Transfected Stable Cell Lines

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  • Human MPL (W515K) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human MPL (W515K) BAF3 Cell Line

Description

Human MPL (W515K) BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. MPL (W515K) BAF3 overexpression cell line is generated by stable integration of exogenous human MPL (W515K) mutant gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The MPL gene encodes the thrombopoietin receptor, which plays a crucial role in hematopoiesis. The W515K mutation activates JAK-STAT signaling in the absence of ligand, contributing to uncontrolled cell proliferation in myeloproliferative neoplasms (MPNs). AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0359C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The MPL (W515K) BAF3 Overexpression Cell Line enables the exploration of cytokine-independent growth mechanisms and the evaluation of JAK pathway inhibitors. It is useful in preclinical drug development for MPN-targeted therapies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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