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Transfected Stable Cell Lines

Human NCOA4_RET BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NCOA4_RET BAF3 Cell Line
Species

Human
Cat.No

ABC-X0072C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human NCOA4_RET BAF3 Cell Line is a lentivirally engineered Ba/F3 cell line overexpressing the NCOA4-RET fusion gene. Cells are maintained at low passage numbers (<P20) and validated at the transcriptional level by qRT-PCR. Target The NCOA4-RET fusion results from chromosomal rearrangements and is observed in thyroid and lung cancers. It activates oncogenic RET kinase signaling, driving cell proliferation and transformation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model is widely used in mechanistic studies of RET fusion-mediated tumorigenesis and for preclinical testing of RET-specific inhibitors. It also facilitates research on resistance mechanisms and combination therapies.

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