Human Neuropathy Peripheral Blood Mononuclear Cells

Description

Human Neuropathy Peripheral Blood Mononuclear Cells (PBMCs) are isolated from patients with clinically confirmed peripheral neuropathies, including diabetic neuropathy, chemotherapy-induced neuropathy, and autoimmune neuropathies (e.g., Guillain-Barré syndrome). These human-derived PBMCs contain immune cell populations (T cells, B cells, monocytes) that demonstrate neuropathy-associated immune activation, including elevated pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6) and increased autoantibody-secreting B cells. The cells exhibit typical mononuclear morphology with intact surface markers and retain functional immune responses, reflecting the critical role of neuroinflammation in peripheral nerve damage. These PBMCs are particularly valuable for studying immune-mediated nerve injury mechanisms and the bidirectional communication between the immune and nervous systems. In addition, these peripheral cells provide a clinically relevant in vitro model for investigating patient-specific immune–nerve interactions and evaluating immunomodulatory therapeutic strategies in peripheral neuropathy research.