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Transfected Stable Cell Lines

Human NRAS (G12C_Q99L) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0282C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human NRAS (G12C_Q99L) BAF3 Cell Line supports investigation of dual NRAS mutations and their cooperative role in cancer development and drug resistance.

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  • Human NRAS (G12C_Q99L) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human NRAS (G12C_Q99L) BAF3 Cell Line

Description

Human NRAS (G12C_Q99L) BAF3 Cell Line is a genetically engineered model developed from murine pro-B Ba/F3 cells with stable overexpression of human NRAS carrying G12C and Q99L mutations. Lentiviral transduction was used to introduce the dual mutant gene construct into host cells. Cultures are maintained below passage 20. Clonal validation is performed by qRT-PCR.
Target
NRAS G12C_Q99L alters both the GTP-binding domain and effector interactions, leading to aberrant signal transduction. This dual mutation enhances oncogenicity and is of interest in advanced preclinical models of myeloid leukemia and melanoma. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0282C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This dual-mutant NRAS model is ideal for studying compound mutation effects, inhibitor resistance profiling, and RAS-pathway therapeutic development in hematologic and solid tumors.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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